Situations OF USE: The knowledge in this database is meant to complement, not substitute for, the abilities and judgment of Health care industry experts. The data isn't intended to cover all attainable takes advantage of, Instructions, safety measures, drug interactions or adverse consequences, nor should it be construed to point that utilization o
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Altogether, our knowledge provide proof for the probable of combining CX-5461 and PARPi for increasing the therapy of HR-deficient HGSOC. We demonstrate that CX-5461 enhances the synthetic lethal interaction of PARPi with HRD and clearly display that CX-5461 has a special mechanism of action to PARPi. Importantly, we characterized BRCA-mutated and
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